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A Comprehensive Review on Medication Used for Warfarin Reversal
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| Azita Haj Hossein Talasaz *, Somayeh Ghaffari |
| School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran |
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Abstract: (2930 Views) |
Warfarin sodium as an anticoagulant, is widely used for the prevention and treatment of venous and arterial thrombosis. As a vitamin K antagonist, warfarin effectively decreases the hepatic production of clotting factors II, VII, IX, and X, along with proteins C and S. While anticoagulants such as warfarin have well-established indications, they are also associated with few side effects such as haemorrhage.
Many patients receiving vitamin K antagonists have an International Normalized Ratio (INR) higher than the target of 2.0 to 3.0 for over 50% of the time, which is followed with increasing risk of bleeding. In this situation the clinical need for emergency reversal of anticoagulation is necessary. There are a number of potential treatment options for anticoagulant reversal, including administration of vitamin K (oral or intravenous), human plasma products [for example, Fresh Frozen Plasma (FFP)], prothrombin complex concentrates (PCCs); concentrates that contain coagu-lation factors II, VII, IX and X), or single coagulation factors such as activated re-combinant factor VII (rFVIIa).
The aim of this paper was to conduct a review of the medical literature and summarize the advantages and risks of the available treatment options for reversing warfarin anticoagulation in patients receiving warfarin.
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| Keywords: Warfarin, Warfarin reversal, Vitamin K, FFP, PCC, rFVIIa |
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Full-Text [PDF 353 kb]
(1254 Downloads)
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Type of Study: Research |
Subject:
General
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