Journal of Medical Council of Iran
Volume 43 - Series of Sessions on Post-Acute COVID-19 Syndrome
jmciri 2025, 43 - Series of Sessions on Post-Acute COVID-19 Syndrome: 64-76 |
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Ahmadi M, Noorbala A A, Mojtahedi H, Assadiasl S, Soleimanifar N, Zolfaghari M, et al . Psychological Complications after COVID-19 Infection. jmciri 2025; 43 (S1) :64-76
URL: http://jmciri.ir/article-1-3452-en.html
URL: http://jmciri.ir/article-1-3452-en.html
Maryam Ahmadi 
, Ahmad Ali Noorbala , Hanieh Mojtahedi , Sara Assadiasl , Narjes Soleimanifar , Mohammadali Zolfaghari , Alireza Esteghamati , Abdolrahman Rostamian , Shahin Akhondzadeh , Mohammad Hossein Nicknam
, Ahmad Ali Noorbala , Hanieh Mojtahedi , Sara Assadiasl , Narjes Soleimanifar , Mohammadali Zolfaghari , Alireza Esteghamati , Abdolrahman Rostamian , Shahin Akhondzadeh , Mohammad Hossein Nicknam
Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran
Abstract: (219 Views)
Background: COVID-19 infection caused psychological complications via direct and indirect effects on the nervous system. In addition to the psychological stress related to the pandemic, quarantine, grief, unemployment, social and interpersonal factors, the SARS-2 virus caused systemic inflammation and directly affected the nervous system, leading to an increase in the prevalence of mental illnesses.
Results: Studies show that COVID-19 infection causes acute and long-term neuropsychiatric complications by causing systemic inflammation, direct penetration into the nervous system, disruption of the hypothalamic-pituitary-adrenal axis, and induction of autoimmunity. These complications usually manifest as depressed mood, insomnia, anxiety, irritability, memory problems, chronic fatigue, post-traumatic stress disorder, and cognitive impairment or brain fog. The high prevalence of these complications leads to decreased productivity, reduced quality of life, and increased strain on the health system. Suggested treatments for these complications include psychotherapy, cognitive behavioral therapy, neurobiological and lifestyle rehabilitation, and pharmacotherapy. Studies have also shown the positive effect of anti-inflammatory drugs, such as celecoxib and famotidine, in improving depression and anxiety after COVID infection, which reinforces the role of inflammation in the neuropsychiatric complications of COVID.
Conclusion: Neuropsychiatric complications after COVID-19 are among the most common problems after infection, causing reduced productivity and numerous social problems. Although there is no definitive treatment for these complications, a variety of behavioral, cognitive, antidepressant, and anti-inflammatory treatments have been proposed
Results: Studies show that COVID-19 infection causes acute and long-term neuropsychiatric complications by causing systemic inflammation, direct penetration into the nervous system, disruption of the hypothalamic-pituitary-adrenal axis, and induction of autoimmunity. These complications usually manifest as depressed mood, insomnia, anxiety, irritability, memory problems, chronic fatigue, post-traumatic stress disorder, and cognitive impairment or brain fog. The high prevalence of these complications leads to decreased productivity, reduced quality of life, and increased strain on the health system. Suggested treatments for these complications include psychotherapy, cognitive behavioral therapy, neurobiological and lifestyle rehabilitation, and pharmacotherapy. Studies have also shown the positive effect of anti-inflammatory drugs, such as celecoxib and famotidine, in improving depression and anxiety after COVID infection, which reinforces the role of inflammation in the neuropsychiatric complications of COVID.
Conclusion: Neuropsychiatric complications after COVID-19 are among the most common problems after infection, causing reduced productivity and numerous social problems. Although there is no definitive treatment for these complications, a variety of behavioral, cognitive, antidepressant, and anti-inflammatory treatments have been proposed
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