TY - JOUR JF - jmciri JO - jmciri VL - 36 IS - 2 PY - 2019 Y1 - 2019/3/01 TI - A Comprehensive Review on Medication Used for Warfarin Reversal TT - مرور جامع بر داروهای مورد استفاده در برگشت اثرات وارفارین N2 - Warfarin sodium as an anticoagulant, is widely used for the prevention and treatment of venous and arterial thrombosis. As a vitamin K antagonist, warfarin effectively decreases the hepatic production of clotting factors II, VII, IX, and X, along with proteins C and S. While anticoagulants such as warfarin have well-established indications, they are also associated with few side effects such as haemorrhage. Many patients receiving vitamin K antagonists have an International Normalized Ratio (INR) higher than the target of 2.0 to 3.0 for over 50% of the time, which is followed with increasing risk of bleeding. In this situation the clinical need for emergency reversal of anticoagulation is necessary. There are a number of potential treatment options for anticoagulant reversal, including administration of vitamin K (oral or intravenous), human plasma products [for example, Fresh Frozen Plasma (FFP)], prothrombin complex concentrates (PCCs); concentrates that contain coagu-lation factors II, VII, IX and X), or single coagulation factors such as activated re-combinant factor VII (rFVIIa). The aim of this paper was to conduct a review of the medical literature and summarize the advantages and risks of the available treatment options for reversing warfarin anticoagulation in patients receiving warfarin. : SP - 67 EP - 73 AU - Haj Hossein Talasaz, Azita AU - Ghaffari, Somayeh AD - School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran KW - Warfarin KW - Warfarin reversal KW - Vitamin K KW - FFP KW - PCC KW - rFVIIa UR - http://jmciri.ir/article-1-2835-en.html ER -