fa بررسی اثر مصرف دارو های SSRI بر میزان انتقال به بخش ICU در بیماران مبتلا به COVID-19 بستری در بیمارستان دکتر مسیح دانشوری عمومى General پژوهشي Research <span style="font-size:12.5pt"><span style="line-height:16.0pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span b="" mitra="" style="font-family:"><span style="color:black"><b><span lang="FA" style="letter-spacing:-.1pt">زمینه:</span></b><span lang="FA" style="letter-spacing:-.1pt"> با توجه به زمان کوتاه مواجهه جهانی با ویروس نوپدید کرونا باید از هراقدامی که میزان مرگ ومیربیماران مبتلا به </span><span dir="LTR" style="font-size:10.5pt"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.1pt">COVID-19</span></span></span><span style="letter-spacing:-.1pt"> را کاهش دهد استقبال گردد. دربررسی متون به استفاده از داروهایی با کاربردهای شناخته شده ای&nbsp; برخورد می کنیم که مهار جدی واکنشهای ایمنی را در پی دارد. از جمله این داروها </span><span dir="LTR" style="font-size:10.5pt"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.1pt">SSRIs</span></span></span><span style="letter-spacing:-.1pt"> هستند. از این رو، هدف پژوهش حاضر سنجش اثربخشی داروهای </span><span dir="LTR" style="font-size:10.5pt"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.1pt">SSRI</span></span></span><span lang="FA" style="letter-spacing:-.1pt">&nbsp; بر میزان انتقال بیماران مبتلا به&nbsp; </span><span dir="LTR" style="font-size:10.5pt"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.1pt">COVID-19</span></span></span><span style="letter-spacing:-.1pt"> به بخش </span><span dir="LTR" style="font-size:10.5pt"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.1pt">ICU</span></span></span><span lang="FA" style="letter-spacing:-.1pt">&nbsp; است.</span></span></span></span></span></span></span><br> <span style="font-size:12.5pt"><span style="line-height:16.0pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span b="" mitra="" style="font-family:"><span style="color:black"><b><span lang="FA" style="letter-spacing:-.1pt">روش کار:</span></b><span lang="FA" style="letter-spacing:-.1pt"> مطالعه حاضرکاربردی و نوع آن کارآزمایی بالینی است. نمونه این پژوهش شامل 180 بیمارمبتلا به </span><span dir="LTR" style="font-size:10.5pt"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.1pt">COVID-19</span></span></span><span style="letter-spacing:-.1pt"> بستری در بیمارستان دکتر مسیح دانشوری است که به صورت هدفمند وارد مطالعه شدند و نیمی از آنها مورد درمان با داروهای </span><span dir="LTR" style="font-size:10.5pt"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.1pt">SSRI</span></span></span><span style="letter-spacing:-.1pt"> تحت نظر روانپزشک قرار گرفتند. سپس میزان انتقال آنها به </span><span dir="LTR" style="font-size:10.5pt"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.1pt">ICU</span></span></span><span style="letter-spacing:-.1pt"> بررسی شد. کلیه داده های حاصل از مطالعه توسط روش های آماری توصیفی و استنباطی به واسطه نرم افزار آماری </span><span dir="LTR" style="font-size:10.5pt"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.1pt">SPSS</span></span></span><span style="letter-spacing:-.1pt"> مورد تجزیه تحلیل آماری قرار گرفتند.</span></span></span></span></span></span></span><br> <span style="font-size:12.5pt"><span style="line-height:16.0pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span b="" mitra="" style="font-family:"><span style="color:black"><b><span lang="FA" style="letter-spacing:-.1pt">یافته</span></b><b><span dir="LTR" style="font-size:10.5pt"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.1pt">‌</span></span></span></b><b><span lang="FA" style="letter-spacing:-.1pt">ها:</span></b><span lang="FA" style="letter-spacing:-.1pt"> 8/52 % زن، 2/47 % مرد بودند. بیمارانی که داروی </span><span dir="LTR" style="font-size:10.5pt"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.1pt">SSRI</span></span></span><span style="letter-spacing:-.1pt"> دریافت کردند بطور معناداری کمتر از بیمارانی که این داروها را دریافت نکرده بودند، به </span><span dir="LTR" style="font-size:10.5pt"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.1pt">ICU</span></span></span><span style="letter-spacing:-.1pt"> منتقل ومورد اینتوباسیون قرار گرفتند(</span><span dir="LTR" style="font-size:10.5pt"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.1pt">(P < 0.01</span></span></span><span lang="FA" style="letter-spacing:-.1pt">. </span></span></span></span></span></span></span><br> <span style="font-size:12.5pt"><span style="line-height:16.0pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span b="" mitra="" style="font-family:"><span style="color:black"><b><span lang="FA" style="letter-spacing:-.1pt">نتیجه</span></b><b><span dir="LTR" style="font-size:10.5pt"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.1pt">‌</span></span></span></b><b><span lang="FA" style="letter-spacing:-.1pt">گیری:</span></b><span lang="FA" style="letter-spacing:-.1pt"> بر اساس مطالعه حاضر داروهای </span><span dir="LTR" style="font-size:10.5pt"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.1pt">SSRI</span></span></span><span style="letter-spacing:-.1pt"> می توانند به بهبود وضعیت روانی وجسمانی بیماران کمک کنند و ریسک انتقال آنها به </span><span dir="LTR" style="font-size:10.5pt"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.1pt">ICU</span></span></span><span style="letter-spacing:-.1pt"> و اینتوبه شدن را کاهش دهند و در نهایت به نجات جان بیماران مبتلا به </span><span dir="LTR" style="font-size:10.5pt"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.1pt">COVID-19</span></span></span><span style="letter-spacing:-.1pt"> یاری رساندند.</span></span></span></span></span></span></span><br> &nbsp; <span style="font-size:11pt"><span style="line-height:150%"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:12.0pt"><span style="line-height:150%"><span arial="" style="font-family:"><span style="color:black">Background:</span></span></span></span></b> <span style="font-size:12.0pt"><span style="line-height:150%"><span arial="" style="font-family:">One year is a limited time to know what to do exactly in confronting with the newly recognized corona virus<span style="color:black">. In this situation we must welcome any action that would reduce the mortality rate due to COVID-19. In literature review, we come across the use of drugs with known uses that lead to serious inhibition of immune reactions. SSRIs are among these drugs. Therefore, the goal of the current research is evaluating the effectiveness of SSRIs on transferring of COVID-19 patients to ICU.</span></span></span></span><span style="font-size:12.0pt"><span style="line-height:150%"><span arial="" style="font-family:"><span style="color:black"></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:150%"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:12.0pt"><span style="line-height:150%"><span arial="" style="font-family:"><span style="color:black">Methods:</span></span></span></span></b><span style="font-size:12.0pt"><span style="line-height:150%"><span arial="" style="font-family:"><span style="color:black"> The research design is practical and the method is clinical trial. The sample of this study included 180 patients with COVID-19 hospitalized in Dr. Massih Daneshvari Hospital. They entered the research by targeted method of sampling. Half of them received SSRI drugs under the supervision of a psychiatrist and then their transference to ICU was examined. All data were analyzed by SPSS using descriptive and inferential statistical methods.</span></span></span></span><span style="font-size:12.0pt"><span style="line-height:150%"><span arial="" style="font-family:"><span style="color:black"></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:150%"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:12.0pt"><span style="line-height:150%"><span arial="" style="font-family:"><span style="color:black">Results: </span></span></span></span></b><span style="font-size:12.0pt"><span style="line-height:150%"><span arial="" style="font-family:"><span style="color:black">52.8% were female, 47.2% were male. According to the results significantly smaller number of patients who had received SSRIs, were transferred to ICU and intubated </span></span></span></span><span style="font-size:12.0pt"><span style="line-height:150%"><span arial="" style="font-family:">(P.V < 0.01)<span style="color:black"> as compared to patients who did not receive SSRIs.</span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:150%"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:12.0pt"><span style="line-height:150%"><span arial="" style="font-family:"><span style="color:black">Conclusion: </span></span></span></span></b><span style="font-size:12.0pt"><span style="line-height:150%"><span arial="" style="font-family:"><span style="color:black">According to the present study, SSRIs can simultaneously improve psychological and physical status and decrease the risk of their transference to ICU and intubation.</span></span></span></span><span style="font-size:12.0pt"><span style="line-height:150%"><span arial="" style="font-family:"> And therefore, </span></span></span><span style="font-size:12.0pt"><span style="line-height:150%"><span arial="" style="font-family:"><span style="color:black">ultimately save the lives of COVID-19 patients. </span></span></span></span></span></span></span><br> &nbsp; کووید-19 , داروهای مهار کننده بازجذب سروتونین, بخش مراقبت های ویژه COVID-19, SSRI drugs, ICU 222 227 http://jmciri.ir/browse.php?a_code=A-10-1-2688&slc_lang=fa&sid=1 بامداد میراب زاده اردکانی 10031947532846006727 10031947532846006727 Yes علیرضا اسلامی نژاد 10031947532846006728 10031947532846006728 No میترا صفا 10031947532846006729 10031947532846006729 No فاطمه قاسم بروجردی 10031947532846006730 10031947532846006730 No جلال حشمت نیا 10031947532846006731 10031947532846006731 No فرزانه حاجی زاده 10031947532846006732 10031947532846006732 No