fa تاثیر تمرین مقاومتی و عصاره آناناس بر بیان ژن ماتریکس متالوپروتئینازهای بافت کبد موش های مبتلا به سرطان ملانوما عمومى General پژوهشي Research <span style="font-size:12.5pt"><span style="line-height:17pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span b="" mitra="" style="font-family:"><span style="color:black"><span class="latin" new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:10.0pt">زمینه</span></b></span><span class="latin" new="" roman="" style="font-family:" times=""><b><span dir="LTR" style="font-size:10.0pt">:</span></b></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">سرطان</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">ملانوما</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">شدیدترین</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">زیر</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">مجموعه</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">سرطان</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">پوست</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">است</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">که</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">قدرت</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">تهاجم</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">بالا</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">و</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">متاستاز</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">سریع</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">به</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">سایر</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">اندامها</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">را</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">دارد</span></span><span class="latin" new="" roman="" style="font-family:" times=""><span dir="LTR" style="font-size:10.0pt">. </span></span><span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">اخیرا</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">نقش</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">تمرینات</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">ورزشی</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">در</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">پیشگیری</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">و</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">درمان</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">سرطان</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">بسیار</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">مورد</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">توجه</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">قرار</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">دارد</span></span><span class="latin" new="" roman="" style="font-family:" times=""><span dir="LTR" style="font-size:10.0pt">. </span></span><span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">آناناس</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">نیز</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">متعلق</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">به</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">خانواده</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">برومولیاسه</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">و</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">زیر</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">خانواده</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">برومولویده</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">می</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">باشد</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">که</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">خواص</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">ضد</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">سرطانی</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">آن</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">مطرح</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">شده</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">است</span></span><span class="latin" new="" roman="" style="font-family:" times=""><span dir="LTR" style="font-size:10.0pt">. </span></span><span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">ماتریکس</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">متالوپروتئینازها</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">خانواده</span></span><span class="latin" new="" roman="" style="font-family:" times=""><span dir="LTR" style="font-size:10.0pt"><span calibri="" style="font-family:">‌</span></span></span><span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">ای</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">از</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">آنزیم</span></span><span class="latin" new="" roman="" style="font-family:" times=""><span dir="LTR" style="font-size:10.0pt"><span calibri="" style="font-family:">‌</span></span></span><span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">های</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">پروتئولیتیک</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">هستند</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">و</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">باعث</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">تخریب</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">ماتریکس</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">خارج</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">سلولی</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">و</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">غشای</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">پایه</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">می</span></span><span class="latin" new="" roman="" style="font-family:" times=""><span dir="LTR" style="font-size:10.0pt"><span calibri="" style="font-family:">‌</span></span></span><span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">شوند</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">و</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">از</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">این</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">لحاظ</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">در</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">فرایندهای</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">فیزیولوژیکی</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">و</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">پاتولوژیکی</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">دارای</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">اهمیت</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">می</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">باشند</span></span><span class="latin" new="" roman="" style="font-family:" times=""><span dir="LTR" style="font-size:10.0pt">. </span></span><span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">گزارش</span></span><span class="latin" new="" roman="" style="font-family:" times=""><span dir="LTR" style="font-size:10.0pt"><span calibri="" style="font-family:">‌</span></span></span><span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">های</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">قبلی</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">نشان</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">داد</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">که</span></span><span class="latin" new="" roman="" style="font-family:" times=""><span dir="LTR" style="font-size:10.0pt"> MMP-<span style="letter-spacing:-.1pt">2</span> </span></span><span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">و</span></span><span class="latin" new="" roman="" style="font-family:" times=""><span dir="LTR" style="font-size:10.0pt"> MMP-<span style="letter-spacing:-.1pt">9</span> </span></span><span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">به</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">طور</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">اساسی</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">در</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">ملانوم</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">های</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">بدخیم</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">بیان</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">می</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">شوند</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">و</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">بیان</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">آنها</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">به</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">شدت</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">با</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">آتیپی</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">ملانوما</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">و</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">تمایززدایی</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">در</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">ضایعات</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">ملانوسیتی</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">مرتبط</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">است</span></span><span class="latin" new="" roman="" style="font-family:" times=""><span dir="LTR" style="font-size:10.0pt">. </span></span><span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">هدف</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">پژوهش</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">حاضر</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">مطالعه</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">تغییرات</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">بیان</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">ژن</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">متالوپروتئین</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">های</span></span><span class="latin" new="" roman="" style="font-family:" times=""><span dir="LTR" style="font-size:10.0pt"> MMP-<span style="letter-spacing:-.1pt">2</span> </span></span><span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">و</span></span><span class="latin" new="" roman="" style="font-family:" times=""><span dir="LTR" style="font-size:10.0pt"> MMP-<span style="letter-spacing:-.1pt">9</span> </span></span><span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">بافت</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">کبد</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">و</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">حجم</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">تومور</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">پس</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">از</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">انجام</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">تمرین</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">مقاومتی</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">و</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">مصرف</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">عصاره</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">آناناس</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">در</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">موش</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">های</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">مبتلا</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">به</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">سرطان</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">ملانوما</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">بود</span></span><span class="latin" new="" roman="" style="font-family:" times=""><span dir="LTR" style="font-size:10.0pt">.</span></span></span></span></span></span></span></span><br> <span style="font-size:12.5pt"><span style="line-height:17pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span b="" mitra="" style="font-family:"><span style="color:black"><span class="latin" new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:10.0pt">روش</span></b></span><span class="latin" new="" roman="" style="font-family:" times=""><b> </b></span><span class="latin" new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:10.0pt">کار</span></b></span><span class="latin" new="" roman="" style="font-family:" times=""><b><span dir="LTR" style="font-size:10.0pt">:</span></b></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">این</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">مطالعه</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">بر</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">روی</span></span><span class="latin" new="" roman="" style="font-family:" times=""><span dir="LTR" style="font-size:10.0pt"> 32 </span></span><span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">سر</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">موش</span></span><span class="latin" new="" roman="" style="font-family:" times=""><span dir="LTR" style="font-size:10.0pt"><span calibri="" style="font-family:">‌</span></span></span><span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">های</span></span><span class="latin" new="" roman="" style="font-family:" times=""><span dir="LTR" style="font-size:10.0pt"><span calibri="" style="font-family:">‌</span></span></span><span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">نژاد</span></span><span class="latin" new="" roman="" style="font-family:" times=""><span dir="LTR" style="font-size:10.0pt"> C57 </span></span><span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">در</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">چهار</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">گروه</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">شامل</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">کنترل،</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">تمرین</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">مقاومتی،</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">عصاره</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">آناناس</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">و</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">تمرین</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">مقاومتی</span></span><span class="latin" new="" roman="" style="font-family:" times=""><span dir="LTR" style="font-size:10.0pt">- </span></span><span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">آناناس</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">انجام</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">شد</span></span><span class="latin" new="" roman="" style="font-family:" times=""><span dir="LTR" style="font-size:10.0pt">. </span></span><span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">پس</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">از</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">القای</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">توموربه</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">موش</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">ها،</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">برنامه</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">تمرین</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">مقاومتی</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">و</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">عصاره</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">دهی</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">آناناس</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">به</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">میزان</span></span><span class="latin" new="" roman="" style="font-family:" times=""><span dir="LTR" style="font-size:10.0pt"> 300mg/kg </span></span><span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">بصورت</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">گاواژ</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">به</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">مدت</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">شش</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">هفته</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">اجرا</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">شد</span></span><span class="latin" new="" roman="" style="font-family:" times=""><span dir="LTR" style="font-size:10.0pt">. </span></span><span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">وزن</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">و</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">حجم</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">تومور</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">موش</span></span><span class="latin" new="" roman="" style="font-family:" times=""><span dir="LTR" style="font-size:10.0pt"><span calibri="" style="font-family:">‌</span></span></span><span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">ها</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">اندازه</span></span><span class="latin" new="" roman="" style="font-family:" times=""><span dir="LTR" style="font-size:10.0pt"><span calibri="" style="font-family:">‌</span></span></span><span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">گیری</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">شد</span></span><span class="latin" new="" roman="" style="font-family:" times=""><span dir="LTR" style="font-size:10.0pt">.</span></span></span></span></span></span></span></span><br> <span style="font-size:12.5pt"><span style="line-height:17pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span b="" mitra="" style="font-family:"><span style="color:black"><span class="latin" new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:10.0pt">یافته</span></b></span><span class="latin" new="" roman="" style="font-family:" times=""><b> </b></span><span class="latin" new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:10.0pt">ها</span></b></span><span class="latin" new="" roman="" style="font-family:" times=""><b><span dir="LTR" style="font-size:10.0pt">: </span></b></span><span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt"><span style="letter-spacing:-.05pt">پس</span></span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt"><span style="letter-spacing:-.05pt">از</span></span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt"><span style="letter-spacing:-.05pt">تهیه</span></span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt"><span style="letter-spacing:-.05pt">خون</span></span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt"><span style="letter-spacing:-.05pt">و</span></span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt"><span style="letter-spacing:-.05pt">نمونه</span></span></span><span class="latin" new="" roman="" style="font-family:" times=""><span dir="LTR" style="font-size:10.0pt"><span calibri="" style="font-family:"><span style="letter-spacing:-.05pt">‌</span></span></span></span><span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt"><span style="letter-spacing:-.05pt">های</span></span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt"><span style="letter-spacing:-.05pt">بافتی</span></span></span><span class="latin" new="" roman="" style="font-family:" times=""><span dir="LTR" style="font-size:10.0pt"><span calibri="" style="font-family:"><span style="letter-spacing:-.05pt">‌</span></span></span></span><span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt"><span style="letter-spacing:-.05pt">،</span></span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt"><span style="letter-spacing:-.05pt">بیان</span></span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt"><span style="letter-spacing:-.05pt">ژن</span></span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt"><span style="letter-spacing:-.05pt">متالوپروتئین</span></span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt"><span style="letter-spacing:-.05pt">های</span></span></span><span class="latin" new="" roman="" style="font-family:" times=""><span dir="LTR" style="font-size:10.0pt"><span style="letter-spacing:-.05pt"> MMP-2 </span></span></span><span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt"><span style="letter-spacing:-.05pt">و</span></span></span><span class="latin" new="" roman="" style="font-family:" times=""><span dir="LTR" style="font-size:10.0pt"><span style="letter-spacing:-.05pt"> MMP-9</span></span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">بافت</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">کبد</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">به</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">روش</span></span><span class="latin" new="" roman="" style="font-family:" times=""><span dir="LTR" style="font-size:10.0pt"> RT-PCR </span></span><span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">انجام</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">شد</span></span><span class="latin" new="" roman="" style="font-family:" times=""><span dir="LTR" style="font-size:10.0pt">. </span></span><span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">سپس</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">داده</span></span><span class="latin" new="" roman="" style="font-family:" times=""><span dir="LTR" style="font-size:10.0pt"><span calibri="" style="font-family:">‌</span></span></span><span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">ها</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">با</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">استفاده</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">آنالیز</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">واریانس</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">یک</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">طرفه،</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">آزمون</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">تحلیل</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">واریانس</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">دو</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">عاملی</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">و</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">تعقیبی</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">مورد</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">تجزیه</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">تحلیل</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">قرار</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">گرفتند</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">و</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">سطح</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">معنی</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">داری</span></span><span class="latin" new="" roman="" style="font-family:" times=""><span dir="LTR" style="font-size:10.0pt"> p&le;0/05 </span></span><span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">در</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">نظرگرفته</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">شد</span></span><span class="latin" new="" roman="" style="font-family:" times=""><span dir="LTR" style="font-size:10.0pt">.</span></span></span></span></span></span></span></span><br> <span style="font-size:12.5pt"><span style="line-height:17pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span b="" mitra="" style="font-family:"><span style="color:black"><span class="latin" new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:10.0pt">نتیجه</span></b></span><span class="latin" new="" roman="" style="font-family:" times=""><b> </b></span><span class="latin" new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:10.0pt">گیری</span></b></span><span class="latin" new="" roman="" style="font-family:" times=""><b><span dir="LTR" style="font-size:10.0pt">:</span></b></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">یافته</span></span><span class="latin" new="" roman="" style="font-family:" times=""><span dir="LTR" style="font-size:10.0pt"><span calibri="" style="font-family:">‌</span></span></span><span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">ها</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">نشان</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">داد</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">در</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">مقایسه</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">با</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">گروه</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">کنترل،</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">تمرین</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">مقاومتی</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">و</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">تمرین</span></span><span class="latin" new="" roman="" style="font-family:" times=""><span dir="LTR" style="font-size:10.0pt">-</span></span><span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">آناناس</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">به</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">کاهش</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">معنی</span></span><span class="latin" new="" roman="" style="font-family:" times=""><span dir="LTR" style="font-size:10.0pt"><span calibri="" style="font-family:">‌</span></span></span><span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">دار</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">حجم</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">تومور</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">و</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">کاهش</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">بیان</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">ژن</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">متالوپروتئین</span></span><span class="latin" new="" roman="" style="font-family:" times=""><span dir="LTR" style="font-size:10.0pt"><span calibri="" style="font-family:">‌</span></span></span><span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">های</span></span><span class="latin" new="" roman="" style="font-family:" times=""><span dir="LTR" style="font-size:10.0pt"> MMP<span style="letter-spacing:-.1pt">-2</span> </span></span><span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">و</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span dir="LTR" style="font-size:10.0pt">MMP-<span style="letter-spacing:-.1pt">9</span> </span></span><span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">بافت</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">کبد</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">منجر</span></span> <span class="latin" new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt">شد</span></span><span class="latin" new="" roman="" style="font-family:" times=""><span dir="LTR" style="font-size:10.0pt">. </span></span></span></span></span></span></span></span><br> &nbsp; <span style="font-size:12pt"><span style="line-height:13pt"><span irmitra="" style="font-family:"><span style="color:black"><span style="font-weight:bold"><span style="font-family:IRMitra">Background:</span><span class="latin" new="" roman="" style="font-family:" times=""><span style="font-size:10.0pt"><span style="font-weight:normal"> Melanoma is the most severe subset of skin cancer, with high invasiveness and rapid metastasis to other organs. Recently, the role of exercise training in the prevention and treatment of cancer has received much attention. Pineapple belongs to the bromolyase family and the bromoloid subfamily, with suggested anti-cancer properties. Matrix metalloproteinases are a family of proteolytic enzymes that destroy the extracellular matrix and basement membrane, and in this sense, they are important in physiological and pathological processes. Previous reports showed that MMP-2 and MMP-9 are essentially expressed in malignant melanomas, and their expression is strongly related to melanoma atypia and dedifferentiation in melanocytic lesions, so the aim of this study is to study the changes in gene expression of metalloproteins MMP-2 and MMP-9 on liver tissue and tumor volume after resistance exercise and consumption of pineapple extract in mice with melanoma cancer. </span></span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:13pt"><span irmitra="" style="font-family:"><span style="color:black"><span style="font-weight:bold"><span style="font-family:IRMitra">Methods: </span><span class="latin" new="" roman="" style="font-family:" times=""><span style="font-size:10.0pt"><span style="font-weight:normal">This study was conducted on 32 heads of C57 mice in four groups including control, resistance training, pineapple extract and resistance training-pineapple. After tumor induction in mice, the program of resistance training and pineapple extract at the dose of 300 mg/kg by gavage was implemented for six weeks. The weight and tumor volume of mice were measured.</span></span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:13pt"><span irmitra="" style="font-family:"><span style="color:black"><span style="font-weight:bold"><span style="font-family:IRMitra">Results: </span><span class="latin" new="" roman="" style="font-family:" times=""><span style="font-size:10.0pt"><span style="font-weight:normal">After obtaining blood and tissue samples, gene expression of MMP-2 and MMP-9 metalloproteins in liver tissue was performed by RT-PCR method. Then the data were analyzed using one-way analysis of variance, two-factor analysis of variance and post hoc test, and the significance level of p&le;0.05 was considered. </span></span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:13pt"><span irmitra="" style="font-family:"><span style="color:black"><span style="font-weight:bold"><span style="font-family:IRMitra">Conclusion: </span><span class="latin" new="" roman="" style="font-family:" times=""><span style="font-size:10.0pt"><span style="font-weight:normal">The findings showed that compared to the control group, resistance training and pineapple-training led to a significant decrease in tumor volume and a decrease in the gene expression of metalloproteins MMP-2 and MMP-9 in the liver tissue.</span></span></span></span></span></span></span></span><br> &nbsp; تمرین مقاومتی, آناناس, سرطان ملانوما, متالوپروتئینها, MMP-2 ,MMP-9 resistance training, pineapple, melanoma cancer, metalloproteins, MMP-2, MMP-9 296 307 http://jmciri.ir/browse.php?a_code=A-10-757-1&slc_lang=fa&sid=1 Foad Asjodi فواد عسجدی 10031947532846007140 10031947532846007140 No Ph.D. Student of Exercise Physiology Hossein Hossein Abed Natanzi حسین عابدنطنزی 10031947532846007141 10031947532846007141 Yes Bahram Abedi بهرام عابدی 10031947532846007142 10031947532846007142 No Mandana Gholami ماندانا غلامی 10031947532846007143 10031947532846007143 No