fa پتانسیل‌های درمانی بوسولیک اسید: یک مرور به‌روز شده برای محققان سم شناسی و فارماکولوژی مروری Review <span style="font-size:11pt"><span style="line-height:17.0pt"><span style="text-autospace:none"><span style="vertical-align:middle"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span lang="AR-SA" style="font-size:15.0pt"><span b="" mitra="" style="font-family:"><span style="color:#16469d">چکیده</span></span></span></b><span dir="LTR" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:#16469d"></span></span></span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:17.0pt"><span style="text-autospace:none"><span style="vertical-align:middle"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span lang="FA" style="font-size:12.5pt"><span b="" mitra="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">زمینه</span></span></span></span></b><b><span dir="LTR" style="font-size:12.5pt"><span b="" mitra="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">:</span></span></span></span></b> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">در</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">سال</span></span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="color:black"><span style="letter-spacing:-.1pt">‌</span></span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">های</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">اخیر،</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">توجه</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">زیادی</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">به</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">استفاده</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">از</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">مواد</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">طبیعی</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">برای</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">درمان</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">بسیاری</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">از</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">بیماری</span></span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="color:black"><span style="letter-spacing:-.1pt">‌</span></span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">های</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">مزمن</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">شده</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">است</span></span></span></span><span dir="LTR" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">. </span></span></span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">بوسولیک</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">اسید</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">که</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">از</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">رزین</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">صمغ</span></span></span></span> <span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black"><span style="letter-spacing:-.1pt">Boswellia</span></span></span></span> <span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black"><span style="letter-spacing:-.1pt">serrata</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">و</span></span></span></span> <span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black"><span style="letter-spacing:-.1pt">Boswellia</span></span></span></span> <span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black"><span style="letter-spacing:-.1pt">carteri</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">به</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">دست</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">می</span></span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="color:black"><span style="letter-spacing:-.1pt">‌</span></span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">آید</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">و</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">از</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">مولکول</span></span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="color:black"><span style="letter-spacing:-.1pt">‌</span></span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">های</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">تری</span></span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="color:black"><span style="letter-spacing:-.1pt">‌</span></span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">ترپن</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">پنج</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">حلقه</span></span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="color:black"><span style="letter-spacing:-.1pt">‌</span></span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">ای</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">تشکیل</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">شده</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">است،</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">از</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">گذشته</span></span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="color:black"><span style="letter-spacing:-.1pt">‌</span></span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">های</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">دور</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">برای</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">درمان</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">بیماری</span></span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="color:black"><span style="letter-spacing:-.1pt">‌</span></span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">های</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">مختلف</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">مورد</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">توجه</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">بوده</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">است</span></span></span></span><span dir="LTR" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">. </span></span></span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">در</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">این</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">مطالعه</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">مروری،</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">هدف</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">ارائه</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">توضیحی</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">عمیق</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">در</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">مورد</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">منشأ،</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">ساختار،</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">فارماکوکینتیک</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">و</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">خصوصاً</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">فعالیت</span></span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="color:black"><span style="letter-spacing:-.1pt">‌</span></span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">های</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">بیولوژیکی</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">مشتقات</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">بوسولیک</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">اسید</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">است</span></span></span></span><span dir="LTR" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">.</span></span></span></span><span dir="LTR" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"></span></span></span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:17.0pt"><span style="text-autospace:none"><span style="vertical-align:middle"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span lang="AR-YE" style="font-size:14.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">روش کار:</span></span></span></b> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">مقالات</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">برای</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">یافتن</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">مطالعات</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">بر</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">روی</span></span></span> <span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">B</span></span></span><span dir="LTR" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">. </span></span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">serrata</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">و</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">مشتقات</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">بوسولیک</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">اسید</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">جدا</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">شده</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">و</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">خواصی</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">مانند</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">ضدسرطان،</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">ضدمیکروبی،</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">ضدالتهابی،</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">ضدآرتریت،</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">کاهش</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="color:black">‌</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">دهنده</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">چربی</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">خون،</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">تعدیل</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="color:black">‌</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">کننده</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">سیستم</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">ایمنی،</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">ضددیابت،</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">محافظ</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">کبد</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">و</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">ضدآسم</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">بررسی</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">شدند</span></span></span><span dir="LTR" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">. </span></span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">بدین</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">منظور</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">کلمات</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">کلیدی</span></span></span> <span dir="LTR" style="font-size:12.0pt"><span style="color:black">&laquo;</span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">Boswellia</span></span></span><span dir="LTR" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">, </span></span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">Boswellic</span></span></span> <span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">acid</span></span></span><span dir="LTR" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">, </span></span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">Therapeutic</span></span></span> <span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">reviews</span></span></span><span dir="LTR" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">, </span></span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">Anti</span></span></span><span dir="LTR" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">-</span></span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">inflammatory</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="color:black">&raquo;</span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">را</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">که</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">مطابق</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">با</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">الگوی</span></span></span> <span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">MeSH</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">انتخاب</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">شده</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">بودند</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">در</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">پایگاه</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="color:black">‌</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">های</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">اطلاعاتی</span></span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">Google</span></span></span> <span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">Scholar </span></span></span><span lang="FA" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">،</span></span></span> <span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">PubMed</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">و</span></span></span> <span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">Scopus</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">به</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="color:black">‌</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">صورت</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">جداگانه</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">و</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">با</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">هم</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">جستجو</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">شدند</span></span></span><span dir="LTR" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">.</span></span></span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:17.0pt"><span style="text-autospace:none"><span style="vertical-align:middle"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span lang="FA" style="font-size:14.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.05pt">یافته</span></span></span></span></b><b><span dir="LTR" style="font-size:14.0pt"><span style="color:black"><span style="letter-spacing:-.05pt">‌</span></span></span></b><b><span lang="FA" style="font-size:14.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.05pt">ها</span></span></span></span></b><b><span dir="LTR" style="font-size:14.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.05pt">:</span></span></span></span></b> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">اثرات</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">ضدتومور</span></span></span> <span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">B</span></span></span><span dir="LTR" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">. </span></span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">serrata</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">به</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">دلیل</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">محتوای</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">تری</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">ترپنوئیدی</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">آن،</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">به</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="color:black">‌</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">ویژه</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">بوسولیک</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">اسید</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">است</span></span></span><span dir="LTR" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">. </span></span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">در</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">میان</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">مشتقات</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">بوسولیک</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">اسید،</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">استیل</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">کتوبوسولیک</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">اسید</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">بیشترین</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">پتانسیل</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">را</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">به</span></span></span> <span dir="LTR" style="font-size:12.0pt"><span style="color:black">‌</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">عنوان</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">یک</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">مولکول</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">سایتوتوکسیک</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">نشان</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">داده</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">است</span></span></span><span dir="LTR" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">. </span></span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">فعال</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="color:black">‌</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">سازی</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">کاسپازها،</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">افزایش</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">بیان</span></span></span> <span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">Bax</span></span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">،</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">کاهش</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">سطح</span></span></span> <span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">NF</span></span></span><span dir="LTR" style="font-size:10.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">-</span></span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">kB</span></span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">،</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">مهار</span></span></span> <span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">TNF</span></span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">،</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">سیکلواکسیژناز</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">و</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">لیپواکسیژناز</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">و</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">سرکوب</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">تولید</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">رادیکال</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="color:black">‌</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">های</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">آزاد</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">همگی</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">نقش</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="color:black">‌</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">های</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">عمده</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="color:black">‌</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">ای</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">در</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">اثرات</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">سیتوتوکسیک</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">و</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">ضدتومور،</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">کاهنده</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="color:black">‌</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">چربی</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="color:black">‌</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">خون،</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">تعدیل</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="color:black">‌</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">کننده</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">سیستم</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">ایمنی،</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">ضددیابت</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">و</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">درمان</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">و</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">پیشگیری</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="color:black">‌</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">کننده</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">از</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">بیماری</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="color:black">‌</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">های</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">نورودژنراتیو</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">این</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">ترکیبات</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">دارند</span></span></span><span dir="LTR" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">.</span></span></span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:17.0pt"><span style="text-autospace:none"><span style="vertical-align:middle"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span lang="FA" style="font-size:14.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">نتیجه</span></span></span></b><b><span dir="LTR" style="font-size:14.0pt"><span style="color:black">‌</span></span></b><b><span lang="FA" style="font-size:14.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">گیری</span></span></span></b><b><span dir="LTR" style="font-size:14.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">:</span></span></span></b> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">تحقیقات</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">پیش</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="color:black">‌</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">بالینی</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">متعدد</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">و</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">طیف</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">وسیعی</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">از</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">کارآزمایی</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="color:black">‌</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">های</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">بالینی</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">نشان</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">داده</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="color:black">‌</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">اند</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">که</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">بوسولیک</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">اسید</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">و</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">مشتقات</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">آن</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">دارای</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">طیف</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">وسیعی</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">از</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">اثرات</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">مفید</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">دارویی</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">در</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">برابر</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">بسیاری</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">از</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">بیماری</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="color:black">‌</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">های</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">مزمن</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">هستند</span></span></span><span dir="LTR" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">. </span></span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">این</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">عوامل</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">می</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="color:black">‌</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">توانند</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">از</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">مکانیسم</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="color:black">‌</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">های</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">متعددی</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">که</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">به</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">پیشرفت</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">بیماری</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">کمک</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">می</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="color:black">‌</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">کنند</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">ممانعت</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">به</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">عمل</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">آورند</span></span></span><span dir="LTR" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">. </span></span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">با</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">این</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="color:black">‌</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">حال،</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">تردیدها</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">در</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">مورد</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">کیفیت</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">فارماکوکینتیک</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">این</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">ترکیب</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">چالش</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">تعیین</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="color:black">‌</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">کننده</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="color:black">‌</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">ای</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">در</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">مسیر</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">توسعه</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">مشتقات</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">بوسولیک</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">اسید</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">به</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="color:black">‌</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">عنوان</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">یک</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">داروی</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">مؤثر</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">بوده</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">است</span></span></span><span dir="LTR" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">. </span></span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">مطالعات</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">زیادی</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">برای</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">یافتن</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">راه</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="color:black">‌</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">هایی</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">برای</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">عبور</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">از</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">این</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">موانع</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">آغاز</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">شده</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">است</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">و</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">پیشرفت</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">در</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">این</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">حوزه</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">تدریجی</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">خواهد</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">بود</span></span></span><span dir="LTR" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">.</span></span></span></span></span></span></span></span></span></span> <span style="font-size:11pt"><span style="line-height:13.0pt"><span style="text-autospace:none"><span style="vertical-align:middle"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:12.0pt"><span style="font-family:IRMitra"><span style="color:black"><span style="letter-spacing:-.05pt">Background: </span></span></span></span></b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black"><span style="letter-spacing:-.05pt">In recent years, much attention has been paid to using natural substances to treat many chronic diseases. Boswellic acid, obtained from the gum resin of Boswellia serrata (B. serrata) and Boswellia carteri, which consists of five-ring triterpene molecules, has been of interest since ancient times to treat various diseases. This review aims to provide an in-depth explanation of the origin, structure, pharmacokinetics, and especially the biological activities of boswellic acid derivatives.</span></span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:13.0pt"><span style="text-autospace:none"><span style="vertical-align:middle"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:12.0pt"><span style="font-family:IRMitra"><span style="color:black"><span style="letter-spacing:-.05pt">Methods: </span></span></span></span></b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black"><span style="letter-spacing:-.05pt">Articles were reviewed to find studies on B. serrata and isolated boswellic acid derivatives and properties such as anti-cancer, anti-microbial, anti-inflammatory, anti-arthritic, blood lipid-lowering, immune modulator, anti-diabetic, liver protective, anti-asthmatic,&nbsp; and anti-Alzheimer disease. For this purpose, the keywords &ldquo;Boswellia, Boswellic acid, Therapeutic reviews, Anti-inflammatory&rdquo; which were selected according to the MeSH pattern were searched in Google Scholar, PubMed, and Scopus databases separately and together.</span></span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:13.0pt"><span style="text-autospace:none"><span style="vertical-align:middle"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:12.0pt"><span style="font-family:IRMitra"><span style="color:black"><span style="letter-spacing:-.05pt">Results:</span></span></span></span></b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black"><span style="letter-spacing:-.05pt"> The antitumor effects of B. serrata are due to its triterpenoid content, especially boswellic acid. Among boswellic acid derivatives, acetylketoboswellic acid has shown the greatest potential as a cytotoxic molecule. Activation of caspases, increase in Bax expression, decrease in NF-kB level, inhibition of TNF, cyclooxygenase, and lipoxygenase, and suppression of free radical production all play major roles in the cytotoxic and antitumor effects, blood lipid-lowering, immune system modulation, antidiabetes and treatment and prevention of neurodegenerative diseases.</span></span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:13.0pt"><span style="text-autospace:none"><span style="vertical-align:middle"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:12.0pt"><span style="font-family:IRMitra"><span style="color:black"><span style="letter-spacing:-.05pt">Conclusion:</span></span></span></span></b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black"><span style="letter-spacing:-.05pt"> Numerous preclinical researches and a wide range of clinical trials have shown that boswellic acid and its derivatives have a wide range of beneficial medicinal effects against many chronic diseases. These factors can inhibit several mechanisms that contribute to disease progression. However, doubts about the pharmacokinetic quality of this compound have been a decisive challenge in the development of boswellic acid derivatives as an effective drug. Many studies have been initiated to find ways to overcome these barriers and progress in this area will be gradual.</span></span></span></span><b><span style="font-size:12.0pt"><span style="font-family:IRMitra"><span style="color:black"><span style="letter-spacing:-.05pt"></span></span></span></span></b></span></span></span></span></span> بوسولیا, بوسولیک اسید, اثرات درمانی, ضدالتهاب Anti-inflammatory, Boswellia, Boswellic acid, Therapeutic reviews 6 17 http://jmciri.ir/browse.php?a_code=A-10-915-5&slc_lang=fa&sid=1 Mohammad Javad Aghababaei محمدجواد آقابابایی mohammad.javadaghababaie@gmail.com 10031947532846009542 10031947532846009542 No Student research committee, Baqiyatallah University of Medical Sciences, Tehran, Iran کمیته تحقیقات و فناوری دانشجویی، دانشگاه علوم پزشکی بقیه الله (عج)، تهران، ایران Mohammad Mashhadi Akbar Boojar محمد مشهدی اکبربوجار mohammadmashhadiakbarboojar@yahoo.com 10031947532846009543 0009-0001-0764-6790 No Student research committee, Mazandaran University of Medical Sciences, Sari, Iran کمیته تحقیقات وفناوری دانشجویی، دانشگاه علوم پزشکی بقیه الله، تهران، ایران Mahdi Mashhadi Akbar Boojar مهدی مشهدی اکبربوجار mahdimashhadi@yahoo.com 0077892550 10031947532846009544 Yes Department of Pharmacology and Toxicology, Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran گروه فارماکولوژی و سم‌شناسی، دانشکده داروسازی، دانشگاه علوم پزشکی بقیه الله (عج)، تهران، ایران