Journal of Medical Council of Iran
مجله علمی پژوهشی سازمان نظام پزشکی ایران
jmciri
Medical Sciences
http://jmciri.ir
1
admin
1562-1073
3041-9956
8
10.22034
14
8888
13
fa
jalali
1404
9
1
gregorian
2025
12
1
43
4
online
1
fulltext
fa
سیلیمارین و سیلیبینین: نگاهی نو به پیشگیری و درمان بیماریهای قلبی عروقی
Silymarin and Silibinin: A New Approach to the Prevention and Treatment of Cardiovascular Diseases
داروسازی
مروری
Review
<p><span style="font-size:11pt"><span style="line-height:17pt"><span style="font-family:Calibri, sans-serif"><span style="color:#000000"><span style="font-style:normal"><span style="font-weight:400"><span style="white-space:normal"><span style="text-decoration:none"><span style="vertical-align:middle"><span style="direction:rtl"><span style="unicode-bidi:embed"><b><span lang="AR-SA" style="font-size:15pt"><span b="" mitra="" style="font-family:"><span style="color:#16469d">چکیده</span></span></span></b><span dir="LTR" lang="EN-US" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:#16469d"></span></span></span></span></span></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:17pt"><span style="font-family:Calibri, sans-serif"><span style="color:#000000"><span style="font-style:normal"><span style="font-weight:400"><span style="white-space:normal"><span style="text-decoration:none"><span style="vertical-align:middle"><span style="direction:rtl"><span style="unicode-bidi:embed"><b><span lang="FA" style="font-size:12.5pt"><span b="" mitra="" style="font-family:"><span style="color:black">زمینه</span></span></span></b><b><span dir="LTR" lang="EN-US" style="font-size:12.5pt"><span b="" mitra="" style="font-family:"><span style="color:black">:</span></span></span></b> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">بیماری</span></span></span><span dir="LTR" lang="EN-US" style="font-size:12.5pt"><span style="color:black"></span></span><span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">های</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">قلبی</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">عروقی</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">به</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">عنوان</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">یک</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">چالش</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">جهانی</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">سلامت،</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">نیاز</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">به</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">راهبرد</span></span></span><span dir="LTR" lang="EN-US" style="font-size:12.5pt"><span style="color:black"></span></span><span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">های</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">درمانی</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">مؤثر</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">دارند</span></span></span><span dir="LTR" lang="EN-US" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">. </span></span></span><span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">سیلیمارین</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">و</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">فعالترین</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">جزء</span></span></span><span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">زیستی</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">آن</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">یعنی</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">سیلیبینین</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">از</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">گیاه</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">خار</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">مریم،</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">به</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">عنوان</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">گزینه</span></span></span><span dir="LTR" lang="EN-US" style="font-size:12.5pt"><span style="color:black"></span></span><span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">های</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">بالقوه</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">در</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">درمان</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">این</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">بیماری</span></span></span><span dir="LTR" lang="EN-US" style="font-size:12.5pt"><span style="color:black"></span></span><span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">ها</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">مورد</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">بررسی</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">قرار</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">گرفته</span></span></span><span dir="LTR" lang="EN-US" style="font-size:12.5pt"><span style="color:black"></span></span><span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">اند</span></span></span><span dir="LTR" lang="EN-US" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">.</span></span></span></span></span></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:17pt"><span style="font-family:Calibri, sans-serif"><span style="color:#000000"><span style="font-style:normal"><span style="font-weight:400"><span style="white-space:normal"><span style="text-decoration:none"><span style="vertical-align:middle"><span style="direction:rtl"><span style="unicode-bidi:embed"><b><span lang="FA" style="font-size:12.5pt"><span b="" mitra="" style="font-family:"><span style="color:black">روش</span></span></span></b><b> </b><b><span lang="FA" style="font-size:12.5pt"><span b="" mitra="" style="font-family:"><span style="color:black">کار</span></span></span></b><b><span dir="LTR" lang="EN-US" style="font-size:12.5pt"><span b="" mitra="" style="font-family:"><span style="color:black">:</span></span></span></b><span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">این</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">تحقیق</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">مروری</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">به</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">تفصیل</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">اثرات</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">سیلیمارین</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">و</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">سیلیبینین</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">را</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">بر</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">عوامل</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">خطر</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">قلبی</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">عروقی</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">از</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">جمله</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">دیابت،</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">چربی</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">خون</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">و</span></span></span><span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">آترواسکلروز</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">بررسی</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">کرد</span></span></span><span dir="LTR" lang="EN-US" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">. </span></span></span><span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">داده</span></span></span><span dir="LTR" lang="EN-US" style="font-size:12.5pt"><span style="color:black"></span></span><span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">های</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">حاصل</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">از</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">مقالات</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">پژوهشی</span></span></span><span dir="LTR" lang="EN-US" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black"> (</span></span></span><span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">مطالعات</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">پیش</span></span></span><span dir="LTR" lang="EN-US" style="font-size:12.5pt"><span style="color:black"></span></span><span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">بالینی</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">و</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">کارآزمایی</span></span></span><span dir="LTR" lang="EN-US" style="font-size:12.5pt"><span style="color:black"></span></span><span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">های</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">بالینی</span></span></span><span dir="LTR" lang="EN-US" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">)</span></span></span><span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">،</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">گزارش</span></span></span><span dir="LTR" lang="EN-US" style="font-size:12.5pt"><span style="color:black"></span></span><span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">های</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">موردی،</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">مرورها</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">و</span></span></span><span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">فراتحلیل</span></span></span><span dir="LTR" lang="EN-US" style="font-size:12.5pt"><span style="color:black"></span></span><span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">های</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">منتشرشده</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">جمع</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">آوری</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">و</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">تجزیه</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">و</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">تحلیل</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">شد</span></span></span><span dir="LTR" lang="EN-US" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">. </span></span></span><span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">جستجوی</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">جامعی</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">در</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">پایگاه</span></span></span><span dir="LTR" lang="EN-US" style="font-size:12.5pt"><span style="color:black"></span></span><span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">های</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">اطلاعاتی</span></span></span> <span dir="LTR" lang="EN-US" style="font-size:10pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">PubMed</span></span></span><span lang="FA" style="font-size:10pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">،</span></span></span><span dir="LTR" lang="EN-US" style="font-size:10pt"><span new="" roman="" style="font-family:" times=""><span style="color:black"> Scopus</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">و</span></span></span> <span dir="LTR" lang="EN-US" style="font-size:10pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">Google</span></span></span> <span dir="LTR" lang="EN-US" style="font-size:10pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">Scholar</span></span></span><span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">برای</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">مطالعات</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">انگلیسی</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">با</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">استفاده</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">از</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">کلمات</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">کلیدی</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">انتخاب</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">شده</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">بر</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">اساس</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">الگوی</span></span></span> <span dir="LTR" lang="EN-US" style="font-size:10pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">MeSH</span></span></span><span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">،</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">شامل</span></span></span> <span dir="LTR" lang="EN-US" style="font-size:12.5pt"><span style="color:black">«</span></span><span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">سیلیمارین،</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">سیلیبینین،</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">بیماری</span></span></span><span dir="LTR" lang="EN-US" style="font-size:12.5pt"><span style="color:black"></span></span><span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">های</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">قلبی</span></span></span><span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">عروقی،</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">دیابت،</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">چربی</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">خون،</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">و</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">آنتی</span></span></span><span dir="LTR" lang="EN-US" style="font-size:12.5pt"><span style="color:black"></span></span><span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">اکسیدان</span></span></span><span dir="LTR" lang="EN-US" style="font-size:12.5pt"><span style="color:black"></span></span><span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">ها</span></span></span><span dir="LTR" lang="EN-US" style="font-size:12.5pt"><span style="color:black">»</span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">انجام</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">شد</span></span></span><span dir="LTR" lang="EN-US" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">. </span></span></span><span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">این</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">تحقیق</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">بر</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">مطالعات</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">اولیه</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">و</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">ثانویه</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">از</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">سال</span></span></span><span dir="LTR" lang="EN-US" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black"> 1995 </span></span></span><span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">تا</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">ژانویه</span></span></span><span dir="LTR" lang="EN-US" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black"> 2025 </span></span></span><span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">متمرکز</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">بود</span></span></span><span dir="LTR" lang="EN-US" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">.</span></span></span></span></span></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:17pt"><span style="font-family:Calibri, sans-serif"><span style="color:#000000"><span style="font-style:normal"><span style="font-weight:400"><span style="white-space:normal"><span style="text-decoration:none"><span style="vertical-align:middle"><span style="direction:rtl"><span style="unicode-bidi:embed"><b><span lang="FA" style="font-size:12.5pt"><span b="" mitra="" style="font-family:"><span style="color:black">یافته</span></span></span></b><b><span dir="LTR" lang="EN-US" style="font-size:12.5pt"><span style="color:black"></span></span></b><b><span lang="FA" style="font-size:12.5pt"><span b="" mitra="" style="font-family:"><span style="color:black">ها</span></span></span></b><b><span dir="LTR" lang="EN-US" style="font-size:12.5pt"><span b="" mitra="" style="font-family:"><span style="color:black">:</span></span></span></b> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">سیلیبینین</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">و</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">سیلیمارین</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">دارای</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">اثرات</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">محافظت</span></span></span><span dir="LTR" lang="EN-US" style="font-size:12.5pt"><span style="color:black"></span></span><span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">کننده</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">قلبی</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">و</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">توانایی</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">کاهش</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">فشار</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">و</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">چربی</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">خون</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">است</span></span></span><span dir="LTR" lang="EN-US" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">. </span></span></span><span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">این</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">عوامل</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">با</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">فعال</span></span></span><span dir="LTR" lang="EN-US" style="font-size:12.5pt"><span style="color:black"></span></span><span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">کردن</span></span></span><span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">مسیرهای</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">آنتی</span></span></span><span dir="LTR" lang="EN-US" style="font-size:12.5pt"><span style="color:black"></span></span><span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">اکسیدانی</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">از</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">سلول</span></span></span><span dir="LTR" lang="EN-US" style="font-size:12.5pt"><span style="color:black"></span></span><span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">ها</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">در</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">برابر</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">استرس</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">اکسیداتیو</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">محافظت</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">می</span></span></span><span dir="LTR" lang="EN-US" style="font-size:12.5pt"><span style="color:black"></span></span><span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">کنند</span></span></span><span dir="LTR" lang="EN-US" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">. </span></span></span><span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">مطالعات،</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">بهبود</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">قابل</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">توجهی</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">را</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">در</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">نمایه</span></span></span><span dir="LTR" lang="EN-US" style="font-size:12.5pt"><span style="color:black"></span></span><span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">های</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">متابولیک</span></span></span><span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">بیماران</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">مبتلا</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">به</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">دیابت</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">نوع</span></span></span><span dir="LTR" lang="EN-US" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black"> 2 </span></span></span><span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">به</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">ویژه</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">زمانی</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">که</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">سیلیبینین</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">به</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">عنوان</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">مکمل</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">همراه</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">با</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">یک</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">رژیم</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">غذایی</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">مناسب</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">مصرف</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">شود،</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">نشان</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">داده</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">اند</span></span></span><span dir="LTR" lang="EN-US" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">. </span></span></span><span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">با</span></span></span><span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">این</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">حال،</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">یافته</span></span></span><span dir="LTR" lang="EN-US" style="font-size:12.5pt"><span style="color:black"></span></span><span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">های</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">بالینی</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">به</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">دلیل</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">محدودیت</span></span></span><span dir="LTR" lang="EN-US" style="font-size:12.5pt"><span style="color:black"></span></span><span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">هایی</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">مانند</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">حجم</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">نمونه</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">کم</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">و</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">تنوع</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">در</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">دوز،</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">به</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">بررسی</span></span></span><span dir="LTR" lang="EN-US" style="font-size:12.5pt"><span style="color:black"></span></span><span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">های</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">بیشتری</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">نیاز</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">دارند</span></span></span><span dir="LTR" lang="EN-US" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">.</span></span></span></span></span></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:17pt"><span style="font-family:Calibri, sans-serif"><span style="color:#000000"><span style="font-style:normal"><span style="font-weight:400"><span style="white-space:normal"><span style="text-decoration:none"><span style="vertical-align:middle"><span style="direction:rtl"><span style="unicode-bidi:embed"><b><span lang="FA" style="font-size:12.5pt"><span b="" mitra="" style="font-family:"><span style="color:black">نتیجه</span></span></span></b><b><span dir="LTR" lang="EN-US" style="font-size:12.5pt"><span style="color:black"></span></span></b><b><span lang="FA" style="font-size:12.5pt"><span b="" mitra="" style="font-family:"><span style="color:black">گیری</span></span></span></b><b><span dir="LTR" lang="EN-US" style="font-size:12.5pt"><span b="" mitra="" style="font-family:"><span style="color:black">:</span></span></span></b> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">سیلیمارین</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">و</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">سیلیبینین</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">می</span></span></span><span dir="LTR" lang="EN-US" style="font-size:12.5pt"><span style="color:black"></span></span><span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">توانند</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">به</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">عنوان</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">مکمل</span></span></span><span dir="LTR" lang="EN-US" style="font-size:12.5pt"><span style="color:black"></span></span><span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">های</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">مؤثر</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">در</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">پیشگیری</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">و</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">درمان</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">بیماری</span></span></span><span dir="LTR" lang="EN-US" style="font-size:12.5pt"><span style="color:black"></span></span><span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">های</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">قلبی</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">عروقی</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">مطرح</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">شوند،</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">زیرا</span></span></span><span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">شواهد</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">موجود،</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">نشان</span></span></span><span dir="LTR" lang="EN-US" style="font-size:12.5pt"><span style="color:black"></span></span><span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">دهنده</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">تأثیر</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">مثبت</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">آنها</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">در</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">کاهش</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">عوامل</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">خطر</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">این</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">بیماری</span></span></span><span dir="LTR" lang="EN-US" style="font-size:12.5pt"><span style="color:black"></span></span><span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">ها</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">است؛</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">با</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">این</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">حال،</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">برای</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">تأیید</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">اثرات</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">و</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">مکانیزم</span></span></span><span dir="LTR" lang="EN-US" style="font-size:12.5pt"><span style="color:black"></span></span><span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">های</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">دقیق</span></span></span><span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">آنها،</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">انجام</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">مطالعات</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">وسیع</span></span></span><span dir="LTR" lang="EN-US" style="font-size:12.5pt"><span style="color:black"></span></span><span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">تر،</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">با</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">طراحی</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">بهتر</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">و</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">همچنین</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">اشکال</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">دارویی</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">نوآورانه</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">و</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">به</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">روزتر</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">ضروری</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">است</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">تا</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">بتوان</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">به</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">نتایج</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">قابل</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">اعتمادتری</span></span></span><span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">دست</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">یافت</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">و</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">این</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">ترکیبات</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">را</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">به</span></span></span><span dir="LTR" lang="EN-US" style="font-size:12.5pt"><span style="color:black"></span></span><span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">طور</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">مؤثر</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">در</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">بالین</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">به</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">کار</span></span></span> <span lang="FA" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">گرفت</span></span></span><span dir="LTR" lang="EN-US" style="font-size:12.5pt"><span style="font-family:Mitra"><span style="color:black">.</span></span></span></span></span></span></span></span></span></span></span></span></span></span></p>
<p><span style="font-size:11pt"><span style="line-height:15.693334px"><span style="font-family:Calibri, sans-serif"><span style="color:#000000"><span style="font-style:normal"><span style="font-weight:400"><span style="white-space:normal"><span style="text-decoration:none"><span style="vertical-align:middle"><b><span lang="EN-US" style="font-size:14pt"><span style="font-family:IRMitra"><span style="color:#16469d"><span style="letter-spacing:-0.05pt">Abstract</span></span></span></span></b><span lang="EN-US" style="font-size:10pt"><span new="" roman="" style="font-family:" times=""><span style="color:black"></span></span></span></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:13pt"><span style="font-family:Calibri, sans-serif"><span style="color:#000000"><span style="font-style:normal"><span style="font-weight:400"><span style="white-space:normal"><span style="text-decoration:none"><span style="vertical-align:middle"><b><span lang="EN-US" style="font-size:12pt"><span style="font-family:IRMitra"><span style="color:black"><span style="letter-spacing:-0.05pt">Background:</span></span></span></span></b><span lang="EN-US" style="font-size:10pt"><span new="" roman="" style="font-family:" times=""><span style="color:black"> Cardiovascular diseases are a global health challenge that requires effective therapeutic strategies. Silymarin and its most active biological component, silibinin, from milk thistle have been investigated as potential options for treating these diseases.</span></span></span></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:13pt"><span style="font-family:Calibri, sans-serif"><span style="color:#000000"><span style="font-style:normal"><span style="font-weight:400"><span style="white-space:normal"><span style="text-decoration:none"><span style="vertical-align:middle"><b><span lang="EN-US" style="font-size:12pt"><span style="font-family:IRMitra"><span style="color:black"><span style="letter-spacing:-0.3pt">Methods:</span></span></span></span></b><span lang="EN-US" style="font-size:10pt"><span new="" roman="" style="font-family:" times=""><span style="color:black"> This review study detailed the effects of silymarin and silibinin on cardiovascular risk factors, including diabetes, dyslipidemia, and atherosclerosis. Data from published research articles (preclinical studies and clinical trials), case reports, reviews, and meta-analyses were collected and analyzed. A comprehensive search in the PubMed, Scopus, and Google Scholar databases for English studies was conducted using keywords selected based on the MeSH pattern, including “Antioxidants, Cardiovascular diseases, Diabetes, Dyslipidemia, Silibinin, Silymarin”. This research focused on primary and secondary studies from 1995 to January 2025. </span></span></span></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:13pt"><span style="font-family:Calibri, sans-serif"><span style="color:#000000"><span style="font-style:normal"><span style="font-weight:400"><span style="white-space:normal"><span style="text-decoration:none"><span style="vertical-align:middle"><b><span lang="EN-US" style="font-size:12pt"><span style="font-family:IRMitra"><span style="color:black"><span style="letter-spacing:-0.3pt">Results:</span></span></span></span></b><span lang="EN-US" style="font-size:10pt"><span new="" roman="" style="font-family:" times=""><span style="color:black"> Silibinin and silymarin have cardioprotective effects and can reduce blood pressure and lipids. These agents protect cells from oxidative stress by activating antioxidant pathways. Studies have shown significant improvements in the metabolic profiles of patients with type 2 diabetes, especially when silibinin is consumed as a supplement alongside an appropriate diet. However, clinical findings require further investigation due to limitations such as small sample sizes and variability in dosages.</span></span></span></span></span></span></span></span></span></span></span></span><br>
<b style="color:#000000; font-style:normal; text-align:start; white-space:normal; text-decoration:none"><span lang="EN-US" style="font-size:12pt"><span style="line-height:17.120001px"><span style="font-family:IRMitra"><span style="color:black"><span style="letter-spacing:-0.3pt">Conclusion:</span></span></span></span></span></b><span lang="EN-US" style="font-size:10pt; text-align:start"><span style="font-style:normal"><span style="font-weight:400"><span style="white-space:normal"><span style="text-decoration:none"><span style="line-height:14.266666px"><span new="" roman="" style="font-family:" times=""><span style="color:black"> Silymarin and silibinin may be considered effective supplements for preventing and treating cardiovascular diseases, as existing evidence indicates their positive impact on reducing associated risk factors. However, to confirm their effects and elucidate the precise mechanisms involved, it is essential to conduct larger studies with improved designs and to explore novel and advanced pharmaceutical formulations. This approach will help achieve more reliable results and facilitate the effective implementation of these compounds in clinical practice</span></span></span></span></span></span></span></span></p>
سیلیمارین, سیلیبینین, بیماریهای قلبی عروقی, دیابت, هایپرلیپیدمی, آنتیاکسیدان.
Antioxidants, Cardiovascular diseases, Diabetes, Dyslipidemia, Silibinin, Silymarin
17
32
http://jmciri.ir/browse.php?a_code=A-10-915-8&slc_lang=fa&sid=1
Mehdi
Rasooli
مهدی
رسولی
mehdirasoolimrx17@gmail.com
10031947532846009825
10031947532846009825
No
Student research committee, Baqiyatallah University of Medical Sciences, Tehran, Iran
کمیته تحقیقات و فناوری دانشجویی، دانشگاه علوم پزشکی بقیه الله (عج)، تهران، ایران
Mohammad
Mashhadi Akbar Boojar
محمد
مشهدی اکبر بوجار
10031947532846009826
10031947532846009826
No
Student Research and Technology Committee, Mazandaran University of Medical Sciences, Sari, Iran
کمیته تحقیقات و فناوری دانشجویی، دانشگاه علوم پزشکی مازندران، ساری، ایران
Mahdi
Mashhadi Akbar Boojar
مهدی
مشهدی اکبربوجار
mahdimashhadi@yahoo.com
0077892550
10031947532846009827
Yes
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran
گروه فارماکولوژی و سم شناسی، دانشکده داروسازی، دانشگاه علوم پزشکی بقیه الله )عج(، تهران، ایران