Journal of Medical Council of Iran
مجله علمی پژوهشی سازمان نظام پزشکی
Volume 43, Issue 1 (2025)
jmciri 2025, 43(1): 70-77 |
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Ghasemi A, Darvishi M, Mohammadi F. Evaluation of hemostasis effect of sterile gauze impregnated with kaolin, alum and chitosan in male wistar rat model. jmciri 2025; 43 (1) :70-77
URL: http://jmciri.ir/article-1-3383-en.html
URL: http://jmciri.ir/article-1-3383-en.html
Abstract: (225 Views)
Abstract
Background: Profuse bleeding is a leading cause of death due to trauma, for which proper hemostatic agents are required. Kaolin mineral and potash alum, due to their ability to promote blood coagulation and rapid hemostatic action, have received more attention than other generations. The aim of this study was to determine the coagulation power ability of these materials for producing dressings with high efficiency and ease.
Methods: 30 male Wistar rats were divided into five groups of positive control (Tabastop), negative control (sterile gas), gauze impregnated with potash alum, chitosan, kaolin and gauze impregnated with all three of these substances. After inducing bleeding by making deep cuts in the femoral area, dressings were placed on the wounds and the amount of bleeding, stopping time and weight of the dressings were measured. The data were analyzed by SPSS statistical software using one-way ANOVA and Tukey`s test, and the significance level was p<0.05.
Results: The highest number of applied dressings belonged to Group 1, and the least belonged to group 6, which showed a significant difference. The longest required time to achieve complete hemostasis was in the group 1 and the least belonged to group 6. (p<0.05). The highest volume of blood loss was related to group 1, while the lowest volume of blood loss was observed in group 6. The difference between these two groups was also significant (p<0.05).
Conclusion: Dressings impregnated with chitosan, kaolin, and potash alum can effectively stop bleeding more quickly than other compounds.
Background: Profuse bleeding is a leading cause of death due to trauma, for which proper hemostatic agents are required. Kaolin mineral and potash alum, due to their ability to promote blood coagulation and rapid hemostatic action, have received more attention than other generations. The aim of this study was to determine the coagulation power ability of these materials for producing dressings with high efficiency and ease.
Methods: 30 male Wistar rats were divided into five groups of positive control (Tabastop), negative control (sterile gas), gauze impregnated with potash alum, chitosan, kaolin and gauze impregnated with all three of these substances. After inducing bleeding by making deep cuts in the femoral area, dressings were placed on the wounds and the amount of bleeding, stopping time and weight of the dressings were measured. The data were analyzed by SPSS statistical software using one-way ANOVA and Tukey`s test, and the significance level was p<0.05.
Results: The highest number of applied dressings belonged to Group 1, and the least belonged to group 6, which showed a significant difference. The longest required time to achieve complete hemostasis was in the group 1 and the least belonged to group 6. (p<0.05). The highest volume of blood loss was related to group 1, while the lowest volume of blood loss was observed in group 6. The difference between these two groups was also significant (p<0.05).
Conclusion: Dressings impregnated with chitosan, kaolin, and potash alum can effectively stop bleeding more quickly than other compounds.
Type of Study: Research |
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