Journal of Medical Council of Iran
مجله علمی پژوهشی سازمان نظام پزشکی
Volume 43, Issue 2 (2025)
jmciri 2025, 43(2): 69-74 |
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Marghoob B, Dormanesh B. Pure Red Cell Aplasia with Parvovirus B19 in a Patient with Renal Transplant. jmciri 2025; 43 (2) :69-74
URL: http://jmciri.ir/article-1-3385-en.html
URL: http://jmciri.ir/article-1-3385-en.html
of Nephrology, Department of Nephrology, Hasheminejad Kidney center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
Abstract: (39 Views)
Abstract
Background: Parvovirus B19 infection is one of the important causes of pure red cell aplasia (PRCA) in kidney transplant patients undergoing immunosuppressive therapy. This condition manifests with severe anemia, reticulocytopenia, and specific bone marrow findings. Diagnosis is based on bone marrow morphology and detection of viral DNA by PCR. Treatment with intravenous immunoglobulin (IVIG) and adjustment of immunosuppressive drugs is effective, but repeated treatment may be necessary due to relapse. Awareness of this condition is essential for timely diagnosis and management of transplant patients with refractory anemia. So far, similar cases of parvovirus B19 infection have been reported in patients following bone marrow transplantation and a few cases following kidney transplantation.
Case Presentation: In this article, our aim is to introduce a patient with parvovirus B19 infection four months after kidney transplantation at Hasheminejad Kidney Center in Tehran, who improved with appropriate diagnosis and treatment.
Conclusion: PRCA is a rare disease, but in adults with isolated persistent anemia who have immunodeficiency, accompanied by reticulocytopenia and no other etiologic evidence for anemia, pure red cell aplasia caused by parvovirus B19 should be ruled out. The main step in treatment for these patients is reducing immunosuppressive therapy.
Background: Parvovirus B19 infection is one of the important causes of pure red cell aplasia (PRCA) in kidney transplant patients undergoing immunosuppressive therapy. This condition manifests with severe anemia, reticulocytopenia, and specific bone marrow findings. Diagnosis is based on bone marrow morphology and detection of viral DNA by PCR. Treatment with intravenous immunoglobulin (IVIG) and adjustment of immunosuppressive drugs is effective, but repeated treatment may be necessary due to relapse. Awareness of this condition is essential for timely diagnosis and management of transplant patients with refractory anemia. So far, similar cases of parvovirus B19 infection have been reported in patients following bone marrow transplantation and a few cases following kidney transplantation.
Case Presentation: In this article, our aim is to introduce a patient with parvovirus B19 infection four months after kidney transplantation at Hasheminejad Kidney Center in Tehran, who improved with appropriate diagnosis and treatment.
Conclusion: PRCA is a rare disease, but in adults with isolated persistent anemia who have immunodeficiency, accompanied by reticulocytopenia and no other etiologic evidence for anemia, pure red cell aplasia caused by parvovirus B19 should be ruled out. The main step in treatment for these patients is reducing immunosuppressive therapy.
Type of Study: case report |
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